反应详情

2-chloro-6-methyl-4-(trifluoromethyl)pyridine (5.0 g) and conc ammonium hydroxide (150 mL) were heated at 180° C. in a steel reaction vessel with mechanical stirring overnight. The contents were allowed to cool and partitioned between CH2Cl2 and water. The CH2 Cl2 layer was dried (MgSO4) and concentrated in vacuo leaving 2-amino-6-methyl-4-(trifluoromethyl)pyridine as a white solid.

1. temperatureto cool
2. custompartitioned between CH2Cl2 and water
3. dry with materialThe CH2 Cl2 layer was dried (MgSO4)
4. concentrationconcentrated in vacuo