8,9-Difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid → HCID 86753473, compound

HRID 1459601Notes

Reaction equation

HRID 1459601 reaction equation
[F:1][C:2]1[C:3](F)=[C:4]2[O:9][CH2:8][CH:7]([CH3:10])[N:6]3[CH:11]=[C:12]([C:17]([OH:19])=[O:18])[C:13](=[O:16])[C:14]([CH:15]=1)=[C:5]23.[OH:21][C:22]([P:34]([O:39][O:40][CH3:41])([O:36][O:37][CH3:38])=[O:35])([P:26]([O:31][O:32][CH3:33])([O:28][O:29][CH3:30])=[O:27])[CH2:23][CH2:24][NH2:25]>>[F:1][C:2]1[C:3]([NH:25][CH2:24][CH2:23][C:22]([OH:21])([P:26]([O:28][O:29][CH3:30])([O:31][O:32][CH3:33])=[O:27])[P:34]([O:36][O:37][CH3:38])([O:39][O:40][CH3:41])=[O:35])=[C:4]2[O:9][CH2:8][CH:7]([CH3:10])[N:6]3[CH:11]=[C:12]([C:17]([OH:19])=[O:18])[C:13](=[O:16])[C:14]([CH:15]=1)=[C:5]23

Participants

3

Reactant 2

HCID 5342788,9-Difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acidHCID 54470893HCID 54470893, compound

Product 1

HCID 86753473HCID 86753473, compound

Procedure

9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid, prepared according to the procedure of example 1 of U.S. Pat. No. 4,382,892, is reacted with 3-hydroxy-3,3-bis(dimethoxyphosphono)-1-propylamine and a quantity of base sufficient to neutralize the acid groups of both reactants and the acid formed in the reaction, thus yielding 9-fluoro-3-methyl-10-[3-hydroxy-3,3-bis(dimethoxyphosphono)-1-propylamino]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de](1,4]benzoxazine-6-carboxylic acid.

Sources & evidence

ORD record
ord-b4f66d4f60c540cf812b5e6d636cef46
Source dataset
uspto-grants-1998_12
Patent number
US05854227

Reaction notes

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