8,9-Difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid → HCID 86753473, compound

Participants

Reaction Steps

9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid, prepared according to the procedure of example 1 of U.S. Pat. No. 4,382,892, is reacted with 3-hydroxy-3,3-bis(dimethoxyphosphono)-1-propylamine and a quantity of base sufficient to neutralize the acid groups of both reactants and the acid formed in the reaction, thus yielding 9-fluoro-3-methyl-10-[3-hydroxy-3,3-bis(dimethoxyphosphono)-1-propylamino]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de](1,4]benzoxazine-6-carboxylic acid.

Provenance & Evidence