反应详情

Prepared from 4-(1,2,4-triazol-1-yl)aniline (EP497512) as described for Intermediate 3, δ (250 MHz, D6 -DMSO) 2.89 (2H, t, J=7.2 Hz, CH2), 3.64-3.74 (2H, m, CH2), 4.67 (1H, t, J=5.3 Hz, OH), 7.29 (1H, d, J=2.3 Hz, Ar--H), 7.47 (1H, dd, J=8.7 and 1.5 Hz, Ar--H), 7.53 (1H, dd, J=8.7 and 2.3 Hz, Ar--H), 7.95 (1H, d, J=1.9 Hz, Ar--H), 8.19 (1H, s, Ar--H), 9.19 (1H, s, Ar--H), 11.10 (1H, s, NH).