Trifluoroacetic acid → HCID 53810121, compound

HRID 1459727Notes

Reaction equation

HRID 1459727 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@@H:10]([CH2:13][S:14]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)(=[O:16])=[O:15])[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:24][C:21]1[CH:20]=[CH:19][C:18]([CH2:17][S:14]([CH2:13][C@@H:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)(=[O:15])=[O:16])=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67651483HCID 67651483, compound

Product 1

HCID 53810121HCID 53810121, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using a similar method to that described in Example 93, step 2, (3R)-1-(tert-butoxycarbonyl)-3-[(4-fluorobenzylsulphonyl)-methyl]pyrrolidine (0.6465 g, 1.81 mmol) was reacted with trifluoroacetic acid (2ml) in dichloromethane (6 ml) to give, after work up, 0.4755 g of the title compound as a white solid, which was used without further purification. δH (360 MHz, CDCl3) 1.55 (1H, m), 2.15 (1H, m), 2.60-2.73 (2H, m), 2.90-3.00 (4H, m), 3.30 (1H, m), 4.21 (2H, s), 7.11 (2H, t, J=8.6 Hz), 7.37-7.41 (2H, m).

Workup

  1. customto give
  2. customafter work up, 0.4755 g of the title compound as a white solid, which was used without further purification

Sources & evidence

ORD record
ord-ca02ee2dd23e4fab9d36828d698f3c65
Source dataset
uspto-grants-1998_12
Patent number
US05854268

Reaction notes

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