Thionyl Chloride → 4-(2-Chloro-phenoxy)-butyryl chloride

HRID 14599Notes

Reaction equation

HRID 14599 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8](O)=[O:9].S(Cl)([Cl:17])=O>>[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]([Cl:17])=[O:9]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 30143434-(2-Chlorophenoxy)butanoic acid

Product 1

HCID 137214424-(2-Chloro-phenoxy)-butyryl chloride

Conditions

Temperature
90 °C

Procedure

To 4-(2-chloro-phenoxy)-butyric acid (250 mg, 1.165 mmol) was added portion wise thionyl chloride (1.69 mL), and the reaction mixture was stirred for 3 hours at 90° C. After such time the excess of thionyl chloride was removed in vacuo to yield the crude title compound which was used in the next step without any further purification.

Workup

  1. customAfter such time the excess of thionyl chloride was removed in vacuo

Sources & evidence

ORD record
ord-fde6eab1543d4615a8db0d0b3ab8f6db
Source dataset
uspto-grants-2010_06
Patent number
US07732452B2

Reaction notes

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