HRID1460044

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID311

Citric acid

C6H8O7

结构：CN(CCCNc1ccc(N=[N+]=[N-])cc1[N+](=O)[O-])CCCNN1C(=O)CC(NC(=O)CSSCCO)C1=O

HCID86751760

未命名化合物

PRODUCTS

生成物

结构：CN(CCCNc1ccc(N=[N+]=[N-])cc1[N+](=O)[O-])CCCNN1C(=O)CC(NC(=O)CSSCCO)C1=O.O=C(O)CC(O)(CC(=O)O)C(=O)O

HCID86751761

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

2 次

PROCEDURE

实验过程

The reaction was carried out in the dark. A flask charged with a solution of 1.15 (2.12 mmole) of N-(4-azido-2-nitrophenyl)-N'-(N-((2-hydroxyethyldithio)-2-ethylamidosuccinimido)-3-aminopropyl)-N'-methyl-1,3-propanediamine in a minimal amount of methanol was treated with a solution of 407.1 mg (2.12 mmole) citric acid dissolved in a minimal amount of methanol at room temperature. After stirring for 5 min the volatiles where removed in vacuo to give 1.4027 g of the desired product as a red solid.

WORKUP

后处理

customremoved in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d43c641aa6fe4a19bd7d3afd3ed44ec0
来源数据集: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05854409
来源说明: uspto-grants-1998_12

反应 SMILES

[N:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][CH2:13][N:14]([CH2:16][CH2:17][CH2:18][NH:19][N:20]2[C:24](=[O:25])[CH2:23][CH:22]([NH:26][C:27](=[O:34])[CH2:28][S:29][S:30][CH2:31][CH2:32][OH:33])[C:21]2=[O:35])[CH3:15])=[C:6]([N+:36]([O-:38])=[O:37])[CH:5]=1)=[N+:2]=[N-:3].[C:39]([OH:51])(=[O:50])[CH2:40][C:41]([CH2:46][C:47]([OH:49])=[O:48])([C:43]([OH:45])=[O:44])[OH:42]>CO>[C:39]([OH:51])(=[O:50])[CH2:40][C:41]([CH2:46][C:47]([OH:49])=[O:48])([C:43]([OH:45])=[O:44])[OH:42].[N:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][CH2:13][N:14]([CH2:16][CH2:17][CH2:18][NH:19][N:20]2[C:24](=[O:25])[CH2:23][CH:22]([NH:26][C:27](=[O:34])[CH2:28][S:29][S:30][CH2:31][CH2:32][OH:33])[C:21]2=[O:35])[CH3:15])=[C:6]([N+:36]([O-:38])=[O:37])[CH:5]=1)=[N+:2]=[N-:3]