Hydrochloric Acid → Buprenorphine component OF alks-5461

HRID 1460137Notes

Reaction equation

HRID 1460137 reaction equation
Cl.[CH3:2][C@@:3]([OH:35])([C:31]([CH3:34])([CH3:33])[CH3:32])[C@@H:4]1[C@:9]2([O:29][CH3:30])[C@@H:10]3[O:24][C:19]4=[C:20]([OH:23])[CH:21]=[CH:22][C:17]5=[C:18]4[C@:11]43[CH2:12][CH2:13][N:14]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[C@H:15]([CH2:16]5)[C@@:6]4([CH2:7][CH2:8]2)[CH2:5]1.Cl>O>[CH3:2][C@@:3]([OH:35])([C:31]([CH3:34])([CH3:33])[CH3:32])[C@@H:4]1[C@:9]2([O:29][CH3:30])[C@@H:10]3[O:24][C:19]4=[C:20]([OH:23])[CH:21]=[CH:22][C:17]5=[C:18]4[C@:11]43[CH2:12][CH2:13][N:14]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[C@H:15]([CH2:16]5)[C@@:6]4([CH2:7][CH2:8]2)[CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9848989(1S,2S,6R,14R,15S,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol;hydrochloride

Product 1

HCID 9848990Buprenorphine component OF alks-5461

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

Buprenorphine base was prepared from its HCl salt. A known amount of commercial buprenorphine HCl was dissolved in water, followed by the addition of saturated solution of Na2HCO3, to precipitate buprenorphine base. The precipitate was then filtered and washed several times with cold deionized water to remove excess Na2HCO3. The white residue was then dried overnight in air. The dried residue was added to a water:ethanol (80:20) mixture, and heated to 60° C., to dissolve the free base, followed by immediate filtration. Upon cooling, the buprenorphine base crystallized. The rhombic shaped crystalline product was then filtered and dried under a gentle stream of nitrogen. The purity of the base was checked by melting point and HPLC assay. The melting point of the base was 210° C., virtually the same as reported in the literature. The purity of the base by HPLC assay was 99%.

Workup

  1. customto precipitate buprenorphine base
  2. filtrationThe precipitate was then filtered
  3. washwashed several times
  4. customto remove excess Na2HCO3
  5. customThe white residue was then dried overnight in air
  6. additionThe dried residue was added to a water:ethanol (80:20) mixture
  7. dissolutionto dissolve the free base
  8. filtrationfollowed by immediate filtration
  9. temperatureUpon cooling
  10. customthe buprenorphine base crystallized
  11. filtrationwas then filtered
  12. customdried under a gentle stream of nitrogen
  13. customwas 210° C.

Sources & evidence

ORD record
ord-5f4c6e89b66841caa48ed1a5dbb0b81f
Source dataset
uspto-grants-1991_12
Patent number
US05069909

Reaction notes

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