Sodium Chloride → HCID 14619867, compound

HRID 1460257Notes

Reaction equation

HRID 1460257 reaction equation
C([O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][CH:21]([C:24]([C:33]3[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=3)([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[OH:25])[CH2:20][CH2:19]2)=[C:10]([O:40][CH3:41])[CH:9]=1)=[O:7])(=O)C.[OH-].[K+].[Cl-].[Na+]>C(O)C.O>[F:32][C:29]1[CH:30]=[CH:31][C:26]([C:24]([C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)([OH:25])[CH:21]2[CH2:20][CH2:19][N:18]([CH2:17][CH2:16][CH2:15][O:14][C:11]3[CH:12]=[CH:13][C:8]([C:6](=[O:7])[CH2:5][OH:4])=[CH:9][C:10]=3[O:40][CH3:41])[CH2:23][CH2:22]2)=[CH:27][CH:28]=1

Participants

6

Reactant 3

HCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 15020345HCID 15020345, compound

Product 1

HCID 14619867HCID 14619867, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 3.9 g (0.0069 mole) of 2-(acetyloxy)-1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone and 1.2 g (0.02 mole) of potassium hydroxide in 50 ml of 95% ethanol and 10 ml of water was heated at reflux under a nitrogen atmosphere for 4 hr. The solution was poured into 600 ml of ice-water and sodium chloride was added until a solid precipitated. The solid was collected by filtration and dried under vacuum to give the title compound. The compound is air sensitive and must be handled in an inert atmosphere.

Workup

  1. temperatureat reflux under a nitrogen atmosphere for 4 hr
  2. additionwas added until a solid
  3. customprecipitated
  4. filtrationThe solid was collected by filtration
  5. customdried under vacuum

Sources & evidence

ORD record
ord-1e2381ad06874fc4800adac88bdf52b5
Source dataset
uspto-grants-1991_12
Patent number
US05070087

Reaction notes

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