Sodium Chloride → HCID 14619867, compound

Participants

Reaction Steps

A solution of 3.9 g (0.0069 mole) of 2-(acetyloxy)-1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone and 1.2 g (0.02 mole) of potassium hydroxide in 50 ml of 95% ethanol and 10 ml of water was heated at reflux under a nitrogen atmosphere for 4 hr. The solution was poured into 600 ml of ice-water and sodium chloride was added until a solid precipitated. The solid was collected by filtration and dried under vacuum to give the title compound. The compound is air sensitive and must be handled in an inert atmosphere.

Provenance & Evidence