Lithium Hydroxide → HCID 14877951, compound

HRID 1460334Notes

Reaction equation

HRID 1460334 reaction equation
[Li+].[OH-].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)=[C:11]([N:17]2[CH:21]=[N:20][N:19]=[N:18]2)[C:12]([O:14]CC)=[O:13])=[CH:6][CH:5]=1>C(O)C.O>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:22]2[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=2)=[C:11]([N:17]2[CH:21]=[N:20][N:19]=[N:18]2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 14877950HCID 14877950, compound

Product 1

HCID 14877951HCID 14877951, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The saponification was performed by the addition of 1.14 mL of 2.0 M LiOH solution to a solution of 0.27 g (0.76 mmole) of ethyl α-[bis(4-fluorophenyl)methylene]-1 H-tetrazole-1-acetate in 5 mL of 95% ethanol at room temperature. After two hours, the crude reaction mixture was diluted with water and washed with diethyl ether (20 mL×2). The free acid in the aqueous layer was regenerated by the addition of aqueous HCl then extracted with diethyl ether, dried and evaporated. The crude acid was dried under high vacuum for 48 hours before it was used in the next step.

Workup

  1. customthe crude reaction mixture
  2. washwashed with diethyl ether (20 mL×2)
  3. additionThe free acid in the aqueous layer was regenerated by the addition of aqueous HCl
  4. extractionthen extracted with diethyl ether
  5. customdried
  6. customevaporated
  7. dry with materialThe crude acid was dried under high vacuum for 48 hours before it

Sources & evidence

ORD record
ord-142487dfea294d7c9780b9355b47b5d6
Source dataset
uspto-grants-1991_12
Patent number
US05070206

Reaction notes

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