1,4-Dioxane → HCID 19981692, compound

Participants

Reaction Steps

Compound (29) (36.0 g; 80.0 mmol) was dissolved in a 4N hydrogen chloride solution in dioxane (400 ml; 1600 mmol) under cooling, and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated and washed with petroleum ether by decantation, followed by concentration to give Compound (30) (HCl salt) (30.8 g; yield, 100%).

Provenance & Evidence