1,4-Dioxane → HCID 19981692, compound

HRID 1460414Notes

Reaction equation

HRID 1460414 reaction equation
C(OC([NH:8][CH:9]([C:23]([N:25]1[CH2:30][CH2:29][CH:28]([CH3:31])[CH2:27][CH2:26]1)=[O:24])[C:10]([S:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)([CH3:12])[CH3:11])=O)(C)(C)C.O1CCOCC1>Cl>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([CH2:14][S:13][C:10]([CH3:11])([CH3:12])[CH:9]([NH2:8])[C:23]([N:25]2[CH2:26][CH2:27][CH:28]([CH3:31])[CH2:29][CH2:30]2)=[O:24])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 19981691HCID 19981691, compound

Product 1

HCID 19981692HCID 19981692, compoundYield 109.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Compound (29) (36.0 g; 80.0 mmol) was dissolved in a 4N hydrogen chloride solution in dioxane (400 ml; 1600 mmol) under cooling, and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated and washed with petroleum ether by decantation, followed by concentration to give Compound (30) (HCl salt) (30.8 g; yield, 100%).

Workup

  1. temperatureunder cooling
  2. concentrationThe reaction mixture was concentrated
  3. washwashed with petroleum ether by decantation
  4. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-552be28872f84a70a1e912493f748d90
Source dataset
uspto-grants-1991_12
Patent number
US05071636

Reaction notes

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