N-Acetyl-D-Glucosamine → N-Acetyl-D-Mannosamine

HRID 1460422Notes

Reaction equation

HRID 1460422 reaction equation
C(N[C@H]1[C@H]([C@@H]([C@@H](CO)O)O)OC(O)(C(=O)O)C[C@@H]1O)(=O)C.[C:22]([NH:25][C@@H:26]1[C@@H:32]([OH:33])[C@H:31]([OH:34])[C@@H:30]([CH2:35][OH:36])[O:29][CH:27]1[OH:28])(=[O:24])[CH3:23]>>[C:22]([NH:25][C@H:26]1[C@@H:32]([OH:33])[C@H:31]([OH:34])[C@@H:30]([CH2:35][OH:36])[O:29][CH:27]1[OH:28])(=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 439174N-Acetyl-D-GlucosamineHCID 439197N-Acetyl-Neuraminic Acid

Product 1

HCID 439281N-Acetyl-D-Mannosamine

Procedure

In accomplishing these and other objects, there is provided a process for preparing N-acetylneuraminic acid, comprising the steps of (a) isomerizing N-acetylglucosamine in a reactor, in the presence of N-acylglucosamine-2-epimerase (E.C. 5.1.3.8), to give N-acetylmannosamine, and (b) reacting the N-acetylmannosamine with pyruvic acid in the presence of N-acetylneuraminic acid pyruvate lyase (E.C. 4.1.3.3) in the same reactor to give N-acetylneuraminic acid, wherein both the epimerase and the lyase are present in a reactor simultaneously, and steps (a) and (b) occur simultaneously.

Workup

  1. customthere is provided a process

Sources & evidence

ORD record
ord-b2aad4be08d047aca7ea5eea1c99cc07
Source dataset
uspto-grants-1991_12
Patent number
US05071750

Reaction notes

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