Pyruvic Acid → N-Acetyl-Neuraminic Acid

HRID 1460424Notes

Reaction equation

HRID 1460424 reaction equation
C(N[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O)(=O)C.C(O)(=O)C(C)=O.C(O)(=O)C(C)=O.[C:28]([NH:31][C@H:32]1[C@H:41]([C@@H:42]([C@@H:44]([CH2:46][OH:47])[OH:45])[OH:43])[O:40][C:35]([OH:39])([C:36](=[O:38])[OH:37])[CH2:34][C@@H:33]1[OH:48])(=[O:30])[CH3:29]>>[C:28]([NH:31][C@H:32]1[C@H:41]([C@@H:42]([C@@H:44]([CH2:46][OH:47])[OH:45])[OH:43])[O:40][C:35]([OH:39])([C:36](=[O:37])[OH:38])[CH2:34][C@@H:33]1[OH:48])(=[O:30])[CH3:29]

Participants

4

Reactant 3

HCID 1060Pyruvic AcidHCID 439281N-Acetyl-D-MannosamineHCID 86745271HCID 86745271, compound

Product 1

HCID 439197N-Acetyl-Neuraminic Acid

Procedure

reacting the N-acetylmannosamine with pyruvic acid in the presence of N-acetylneuraminic acid pyruvate lyase (E.C. 4.1.3.3) in the same reactor to give N-acetylneuraminic acid, wherein both the epimerase and the lyase are present in a reactor simultaneously, and steps (a) and (b) occur simultaneously.

Sources & evidence

ORD record
ord-ca3d4d646a014a0f9ea8f880cbf530ec
Source dataset
uspto-grants-1991_12
Patent number
US05071750

Reaction notes

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