1-(2-Pyrimidinyl)piperazine → HCID 15020939, compound

HRID 1460428Notes

Reaction equation

HRID 1460428 reaction equation
[CH2:1]([O:8][C:9]1[C:14]2[C:15](=[O:26])[N:16]([CH2:21][CH2:22][CH2:23][CH2:24]Br)[C:17](=[O:20])[CH2:18][O:19][C:13]=2[CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:27]1[CH:32]=[CH:31][CH:30]=[N:29][C:28]=1[N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>O1CCOCC1>[CH2:1]([O:8][C:9]1[C:14]2[C:15](=[O:26])[N:16]([CH2:21][CH2:22][CH2:23][CH2:24][N:36]3[CH2:37][CH2:38][N:33]([C:28]4[N:27]=[CH:32][CH:31]=[CH:30][N:29]=4)[CH2:34][CH2:35]3)[C:17](=[O:20])[CH2:18][O:19][C:13]=2[CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 15020879HCID 15020879, compound

Product 1

HCID 15020939HCID 15020939, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 202 mg amount of the compound of Example 13 was dissolved in 20 ml of dioxane, and 242 mg (3 equivalents) of 1-(2-pyrimidinyl)piperazine was added, followed by heating under reflux for 7 hours. The reaction treatment and purification were conducted as in Example 75, to give 195 mg of the desired compound (yield 79%). The maleic acid salt was obtained in a conventional manner.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 7 hours
  3. customThe reaction treatment and purification

Sources & evidence

ORD record
ord-b985701d027346faa03eb0d84bec6af7
Source dataset
uspto-grants-1991_12
Patent number
US05071845

Reaction notes

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