Triethylamine → HCID 19981929, compound

HRID 1460492Notes

Reaction equation

HRID 1460492 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][N:10]=1.C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][N:10]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 154753442-(Pyrimidin-4-yl)ethan-1-ol

Product 1

HCID 19981929HCID 19981929, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of methanesulphonyl chloride (137 mg) in dichloromethane (2 ml) was added to a solution of 4-(2-hydroxyethyl)pyrimidine (124 mg) (prepared by the method of C. G. Overberger and I. C. Kogon, JACS, 76, 1879 (1954)) and triethylamine (121 mg) in dichloromethane (10 ml), the mixture stirred at room temperature for 3 hours and evaporated under reduced pressure to give the crude title compound as a pale yellow oil which was used directly in Example 10 without further purification.

Workup

  1. customprepared by the method of C
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-5ca7e4b745864d64be87d29d6ffcf93d
Source dataset
uspto-grants-1991_12
Patent number
US05071844

Reaction notes

Loading…