m-Chloroperbenzoic acid → HCID 22841642, compound

HRID 1460493Notes

Reaction equation

HRID 1460493 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.Cl.[NH:13]1[CH2:17][CH2:16][CH2:15][C@H:14]1[CH2:18][N:19]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[CH2:23][S:22][C:21]2[CH:30]=[CH:31][CH:32]=[CH:33][C:20]1=2>C(Cl)(Cl)Cl>[NH:13]1[CH2:17][CH2:16][CH2:15][C@H:14]1[CH2:18][N:19]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[CH2:23][S:22](=[O:9])[C:21]2[CH:30]=[CH:31][CH:32]=[CH:33][C:20]1=2

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 67834687HCID 67834687, compound

Product 1

HCID 22841642HCID 22841642, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of meta-chloroperbenzoic acid (105 mg) in chloroform (5 ml) was added to a solution of (S)-5,11-dihydro-5-(2-pyrrolidinylmethyl)dibenzo[b,e][1,4]thiazepine hydrochloride (see Preparation 21) (200 mg) in chloroform (10 ml) and the mixture stirred at room temperature for 4 hours, washed with 10% aqueous sodium carbonate solution, dried over sodium sulphate and evaporated under reduced pressure to give the title compound as a colourless gum, (180 mg, 96%).

Workup

  1. washwashed with 10% aqueous sodium carbonate solution
  2. dry with materialdried over sodium sulphate
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-48ae0011ea34478d9463f38f0908886a
Source dataset
uspto-grants-1991_12
Patent number
US05071844

Reaction notes

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