Benzyl Chloride → 3-benzyl-2-(1-methylpiperidin-3-yl)-3H-imidazo [4,5-b] pyridine

HRID 1460503Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([C:8]2[NH:16][C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)[CH2:3]1.[CH2:17](Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([N:16]1[C:11]2=[N:12][CH:13]=[CH:14][CH:15]=[C:10]2[N:9]=[C:8]1[CH:4]1[CH2:5][CH2:6][CH2:7][N:2]([CH3:1])[CH2:3]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

Reactant 2

HCID 7503Benzyl Chloride

HCID 178480253HCID 178480253, compound

Product 1

HCID 216476273-benzyl-2-(1-methylpiperidin-3-yl)-3H-imidazo [4,5-b] pyridine

Procedure

Operation is carried out similarly to the description of Example 5 with the difference that 2-(1-methylpiperidin-3-yl)3H-imidazo [4,5-b] pyridine is reacted with benzylchloride to obtain 3-benzyl-2-(1-methylpiperidin-3-yl)-3H-imidazo [4,5-b] pyridine as an oil, after purification by chromatography on silicagel column (CHCl3 -CH3OH 9:1).

Sources & evidence

ORD record: ord-fa99d04252cc43818c927e1228b73094
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05071855

Reaction notes

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