3-Methylbenzaldehyde → HCID 19982204, compound

HRID 1460564Notes

Reaction equation

HRID 1460564 reaction equation
[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]([F:14])[C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[C:15]1([CH3:23])[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]=O)[CH:16]=1.[BH4-].[Na+]>>[F:14][C:10]1[C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=[C:2]([NH:1][CH2:23][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)[C:11]=1[O:12][CH3:13]

Participants

4

Reactant 3

HCID 121053-MethylbenzaldehydeHCID 4311764Sodium borohydrideHCID 15675938HCID 15675938, compound

Product 1

HCID 19982204HCID 19982204, compound

Procedure

Following the procedure of Example 13, 6-amino-4-fluoro-5-methoxy-2-benzoxazolone (Example 11) was reacted with 3-tolualdehyde and the resulting product was reduced with sodium borohydride to give the title compound: m.p. 160°-161° C.

Sources & evidence

ORD record
ord-f5e32a37837148308227906092685c4c
Source dataset
uspto-grants-1991_12
Patent number
US05071863

Reaction notes

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