HCID 15657628, compound → HCID 15657635, compound

HRID 1460582Notes

Reaction equation

HRID 1460582 reaction equation
[CH3:1][C:2]1([CH3:17])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([O:14]CC)=[O:13])=[CH:4][CH2:3]1.C[Si](C)(C)[O-].[K+]>C1COCC1>[CH3:1][C:2]1([CH3:17])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH2:3]1

Participants

4

Reactant 2

HCID 15657628HCID 15657628, compoundHCID 23668039Potassium trimethylsilanolate

Product 1

HCID 15657635HCID 15657635, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the compound from Example 41 (15.5 g, 71.7 mmol) and potassium trimethylsilanolate (17.4 g) in 100 ml of THF was refluxed for 24 hours. After workup the title compound (8.7 g, 52%) was obtained as a white solid.

Sources & evidence

ORD record
ord-7973501fe5e940a1861521b4df7a3534
Source dataset
uspto-grants-1991_12
Patent number
US05071853

Reaction notes

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