HCID 19107104, compound → HCID 19107020, compound

HRID 1460586Notes

Reaction equation

HRID 1460586 reaction equation
[O:1]=[C:2]1[CH2:15][CH:14]2[C:9]([C:16]([O:18]C)=[O:17])([CH2:10][CH2:11][CH2:12][CH2:13]2)[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.C[Si](C)(C)[O-].[K+]>C1COCC1>[O:1]=[C:2]1[CH2:15][CH:14]2[C:9]([C:16]([OH:18])=[O:17])([CH2:10][CH2:11][CH2:12][CH2:13]2)[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2

Participants

4

Reactant 2

HCID 19107104HCID 19107104, compoundHCID 23668039Potassium trimethylsilanolate

Product 1

HCID 19107020HCID 19107020, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the compound from Example 51 (1.5 g, 5.8 mmol) and potassium trimethylsilanolate (1.5 g, 11.6 mmol) in 25 ml THF was refluxed 60 hours. Workup as before and chromatography on silica gel gave the title compound (1.1 g, 78%).

Sources & evidence

ORD record
ord-8301fd8725a34dda9f32108f05d4e2f4
Source dataset
uspto-grants-1991_12
Patent number
US05071853

Reaction notes

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