HCID 19106972, compound → HCID 19107117, compound

HRID 1460591Notes

Reaction equation

HRID 1460591 reaction equation
[CH:1]1[C:10]2[C:9]3([C:15]([O:17]CC)=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH:8]3[CH2:7][O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.C[Si](C)(C)[O-].[K+]>C1COCC1>[CH:1]1[C:10]2[C:9]3([C:15]([OH:17])=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH:8]3[CH2:7][O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 19106972HCID 19106972, compoundHCID 23668039Potassium trimethylsilanolate

Product 1

HCID 19107117HCID 19107117, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the compound from Example 69 (4.9 g, 18.6 mmol) and potassium trimethylsilanolate (4.5 g) in 75 ml THF was refluxed for 23 hours. Workup as previously described gave the title compound as a white solid (4.25 g).

Sources & evidence

ORD record
ord-92a4527ed18d49e99a5146fb68a116a5
Source dataset
uspto-grants-1991_12
Patent number
US05071853

Reaction notes

Loading…