Hydrochloric Acid → HCID 19107094, compound

HRID 1460594Notes

Reaction equation

HRID 1460594 reaction equation
COC(=O)[NH:4][C:5]12[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[CH2:9][O:8][C:7]1[CH:15]=[CH:16][CH:17]=[CH:18][C:6]2=1.C[Si](C)(C)[O-].[K+].[ClH:26]>>[ClH:26].[CH:18]1[C:6]2[C:5]3([NH2:4])[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]3[CH2:9][O:8][C:7]=2[CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 23668039Potassium trimethylsilanolateHCID 131717093HCID 131717093, compound

Product 1

HCID 19107094HCID 19107094, compound

Procedure

A solution of the compound from Example 72 (0.3 g, 1.15 mmol) and potassium trimethylsilanolate (0.3 g, 2.34 mmol) was refluxed for 21 hours. Workup followed by treatment of the free amine with isopropanolic HCl gave the title compound (0.24 g), mp 230°-232° C.

Sources & evidence

ORD record
ord-52c9add385c84308bed9abfdc2821925
Source dataset
uspto-grants-1991_12
Patent number
US05071853

Reaction notes

Loading…