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HRID1460614

反应详情

EQUATION

反应方程式

HRID 1460614 的结构方程式

REACTANTS

反应物

3
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC1(C)Oc2ccc(C#N)cc2[C@@H](OC2=CC(=O)CC2)[C@@H]1O
HCID129348

3-Hydroxy-2,2-dimethyl-4-[(3-oxocyclopent-1-en-1-yl)oxy]-3,4-dihydro-2H-1-benzopyran-6-carbonitrile

C17H17NO4

结构：NC1=CC(=O)CC1
HCID12291440

3-aminocyclopent-2-en-1-one

C5H7NO

PRODUCTS

生成物

1
结构：CC1(C)Oc2ccc(C#N)cc2[C@@H](NC2=CC(=O)CC2)[C@@H]1O
HCID14301304

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

2.41 g of the epoxide of example 1 were solved in 36 ml of dimethylsulfoxide under a protective gas, and 360 mg of sodium hydrid were added. To this stirred suspension was added 1.71 g of 3-amino-cyclopent-2-en-1-one (Chem. Ber. 103, 2403 [1970]) in portions. After 21 hours, the reaction solution was worked up in an aqueous manner and extracted with ethyl acetate. The usual further processing and recrystallisation of the product obtained from ethyl acetate yielded white crystals having a m.p. of 174°-176° C.

WORKUP

后处理

  1. additionwere added
  2. extractionextracted with ethyl acetate
  3. customThe usual further processing and recrystallisation of the product
  4. customobtained from ethyl acetate yielded white crystals