HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[2-oxofuran-4(5H)-ylamino]-2H-benzopyran-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sdz pco 400 | HCID 129348 | — |
| Reactant | 4-amino-5H-furan-2-one | HCID 13374861 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[2-oxofuran-4(5H)-ylamino]-2H-benzopyran-6-carbonitrile | HCID 14301306 | — |
Reaction Steps
34,5 mg of the epoxide of example 1 and 17 mg of 4-Amino-2-(5H)-furanone (CAS 92089-08-2) are reacted analogously to example 5 with sodium hydride in dimethylsulfoxide. The usual working up yields yellowish crystalls of the title compound having a m.p. of 182° C. (from ethanol/dichloromethane, decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05071871 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-88178ba757f84ac4a21ff08f29b00f81 |
| Source note | uspto-grants-1991_12 |