HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[N-methyl-N-(3-oxo-cyclopent-1-enyl)amino]-2H-1-benzopyran-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sdz pco 400 | HCID 129348 | — |
| Reactant | 3-(Methylamino)cyclopent-2-en-1-one | HCID 13217907 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[N-methyl-N-(3-oxo-cyclopent-1-enyl)amino]-2H-1-benzopyran-6-carbonitrile | HCID 14301310 | — |
Reaction Steps
4.02 g of the epoxide of example 1 are reacted analogously to example 5 with 2.44 g N-methyl-3-amino-cyclopent-2-en-1-on and 660 mg of sodium hydride (80%) in dimethylsulfoxide. Usual working up yields crystalls of the title compound having a m.p. of 271°-74° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05071871 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-92f61fe3a9de43a99da90180efff69fa |
| Source note | uspto-grants-1991_12 |