HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[N-methyl-N-(N-methyl-2-oxo-pyrrol-4(5H)-yl)amino]-2 H-1-benzopyran-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sdz pco 400 | HCID 129348 | — |
| Reactant | 4-(N-methyl-amino)-N-methyl-2(5H)-pyrrolon | HCID 14301350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[N-methyl-N-(N-methyl-2-oxo-pyrrol-4(5H)-yl)amino]-2 H-1-benzopyran-6-carbonitrile | HCID 14301314 | — |
Reaction Steps
402 mg of the epoxide of example 1 in 4 ml of dimethylsulfoxide are reacted analogously to example 5 with 60 mg of sodium hydride and 25.2 mg of the amide obtained above. Usual work up yields the title compound having a m.p. of 266°-69° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05071871 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-531a850a58ac49578d369115c2acfe28 |
| Source note | uspto-grants-1991_12 |