Isobutyryl chloride → 8-Methoxy-2-iso-butyramido-tetralin

HRID 1460628Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2.[C:14](Cl)(=[O:18])[CH:15]([CH3:17])[CH3:16]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([NH:13][C:14](=[O:18])[CH:15]([CH3:17])[CH3:16])[CH2:9][CH2:8]2

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 101979338-Methoxy-2-aminotetralin

Product 1

HCID 104446588-Methoxy-2-iso-butyramido-tetralinYield 71%

Procedure

Using a procedure similar to that described in Example 1, 0.22 g of 8-methoxy-2-amino-tetralin yielded 0.18 g (71%) of 8-methoxy-2-iso-butyramido-tetralin following treatment with iso-butyryl chloride.

Sources & evidence

ORD record: ord-fb7076c9978747ee979154ba5f1207bb
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05071875

Reaction notes

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