HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (R)-1-[2-[[2-(4-Fluoro-2-methylphenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl piperidine-3-carboxylate--hydrogen chloride (1/1) | HCID 12896004 | — |
| Reactant | 1-[2-(2-Bromoethoxy)-1-(2-methylphenyl)ethenyl]-4-fluoro-2-methylbenzene | HCID 54296314 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (R)-1-[2-[[2-(4-Fluoro-2-methylphenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester | HCID 54574747 | — |
Reaction Steps
1-[2-(2-Bromethoxy)-1-(2-methylphenyl)ethenyl]-4-fluoro-2-methylbenzene (1.15 g, 0.0033 mol), the (R)-enantiomer of ethyl nipecotate hydrochloride (see example 1) (1.92 g, 0.0099 mol) and dried potassium carbonate (2.28 g, 0.0165 mol) were stirred in acetone (100 ml) at reflux temperature for 54 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05071859 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-e19f682f29964207af75a850c230b58b |
| Source note | uspto-grants-1991_12 |