Acetic Anhydride → HCID 19086875, compound

HRID 1460692Notes

Reaction equation

HRID 1460692 reaction equation
[OH:1][N:2]=[C:3]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[CH2:15][CH2:14]3)=[O:10])[CH2:5][CH2:4]1.[C:22](OC(=O)C)(=[O:24])[CH3:23].C(N(CC)CC)C>C(Cl)Cl>[C:22]([O:1][N:2]=[C:3]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[CH2:15][CH2:14]3)=[O:10])[CH2:5][CH2:4]1)(=[O:24])[CH3:23]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 19086873HCID 19086873, compound

Product 1

HCID 19086875HCID 19086875, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

15 Grams of 6-(4-hydroxyimino-1-piperidylcarbonyl)-3,4-dihydrocarbostyril, 11.4 ml of acetic anhydride and 31.8 ml of triethylamine in 300 ml of methylene chloride solution were mixed together and stirred at room temperature overnight. The reaction mixture was poured into ice-water, and extracted with chloroform. The chloroform extract was dried with anhydrous sodium carbonate, then the solvent was removed by evaporation to yield 16.5 g of 6-(4-acetyloxyimino-1-piperidylcarbonyl)-3,4-dihydrocarbostyril.

Workup

  1. extractionextracted with chloroform
  2. extractionThe chloroform extract
  3. dry with materialwas dried with anhydrous sodium carbonate
  4. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-2dc05e2fcefa45c2b577d0b24ef8a10c
Source dataset
uspto-grants-1991_12
Patent number
US05071856

Reaction notes

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