反应详情

A mixture of methyl 3,4-diphenyl-1H-pyrazole 1-octanoate (3.40 g, 9 mmol), lithium hydroxide hydrate (1.13 g, 27 mmol), methanol (60 mL), and water (10 mL) was heated at reflux on a steam bath. After 15 minutes, the solution was concentrated in vacuo, diluted with water and 2N HCl solution until pH=1. The mixture was extracted with methylene chloride, the combined extracts dried, and the solvent evaporated to leave an oil. Dissolution in diethyl ether followed by the addition of hexanes provided 3,4-diphenyl-1H-pyrazole-1-octanoic acid (2.80 g, 86%); m.p.=108°-110° C. MS(CI): m/e=363 (MH+).

1. temperaturewas heated
2. temperatureat reflux on a steam bath
3. concentrationthe solution was concentrated in vacuo
4. additiondiluted with water and 2N HCl solution until pH=1
5. extractionThe mixture was extracted with methylene chloride
6. customthe combined extracts dried
7. customthe solvent evaporated
8. customto leave an oil