反应详情

16 g (55 mmol) of ethyl 2-benzyl-8-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is concentrated, and the residue is dissolved in 50 ml of water and rendered alkaline with potassium carbonate. The mixture is extracted five times using 50 ml of chloroform each time, the extracts are dried over K2CO3 and concentrated, and the residue is distilled.

1. concentrationThe mixture is concentrated
2. dissolutionthe residue is dissolved in 50 ml of water
3. extractionThe mixture is extracted five times
4. dry with materialthe extracts are dried over K2CO3
5. concentrationconcentrated
6. distillationthe residue is distilled