HCID 19100973, compound → HCID 19100943, compound

HRID 1460798Notes

Reaction equation

HRID 1460798 reaction equation
[F:1][CH2:2][C:3]12[CH2:10][N:9](C(OCC)=O)[CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2>Cl>[F:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2

Participants

3

Reactant 1

HCID 19100973HCID 19100973, compound

Product 1

HCID 19100943HCID 19100943, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl -2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight in 100 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 20 ml of water, the mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

Workup

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

Sources & evidence

ORD record
ord-8c248f55d9ea445285a4869bd925270d
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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