Toluene → HCID 19100964, compound

HRID 1460807Notes

Reaction equation

HRID 1460807 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:2].C1(C)C=CC=CC=1.[CH2:22]([N:25]([CH2:31][CH:32]=O)[C:26](=[O:30])[O:27][CH2:28][CH3:29])[CH:23]=[CH2:24]>O>[CH2:7]([N:6]1[CH:5]([C:4]([O:3][CH2:1][CH3:2])=[O:14])[CH2:24][CH:23]2[CH:32]1[CH2:31][N:25]([C:26]([O:27][CH2:28][CH3:29])=[O:30])[CH2:22]2)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 80908N-Benzylglycine ethyl esterHCID 11084330Ethyl allyl(2-oxoethyl)carbamate

Product 1

HCID 19100964HCID 19100964, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

50 g (0.25 mol) of N-benzylglycine ethyl ester in 1 1 of toluene are heated under reflux in a water separator and 43 g (0.25 mol) of ethyl N-allyl-N-(2-oxoethyl) -carbamate are added dropwise during the course of two hours. The mixture is heated under reflux until water no longer separates and concentrated, and the residue is distilled.

Workup

  1. additionare added dropwise during the course of two hours
  2. temperatureThe mixture is heated
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-5698b08720e74971810df6f41f337fa5
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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