HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 5-chloro-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-N-(N'-methylcarbamoyl)-4-pyrimidine amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 5-chloro-N-chlorocarbonyl-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-4-pyrimidine amine | HCID 15010197 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-chloro-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-N-(N'-methylcarbamoyl)-4-pyrimidine amine | HCID 15010199 | — |
Reaction Steps
Into a solution of 1.0 g of 5-chloro-N-chlorocarbonyl-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-4-pyrimidine amine dissolved in 20 ml of toluene was added under stirring 1 ml of an aqueous 40% monomethylamine solution, and the mixture was stirred at room temperature for one hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05073558 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-90dc54b13bfd454faef3921d52e41dfe |
| Source note | uspto-grants-1991_12 |