Methylamine → 5-chloro-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-N-(N'-methylcarbamoyl)-4-pyrimidine amine

HRID 1460957Notes

Reaction equation

HRID 1460957 reaction equation
[Cl:1][C:2]1[C:3]([N:9]([C:25](Cl)=[O:26])[CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][O:21][CH2:22][CH3:23])=[CH:15][C:14]=2[CH3:24])=[N:4][CH:5]=[N:6][C:7]=1[CH3:8].[CH3:28][NH2:29]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([N:9]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][O:21][CH2:22][CH3:23])=[CH:15][C:14]=2[CH3:24])[C:25](=[O:26])[NH:29][CH3:28])=[N:4][CH:5]=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 150101975-chloro-N-chlorocarbonyl-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-4-pyrimidine amine

Product 1

HCID 150101995-chloro-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-N-(N'-methylcarbamoyl)-4-pyrimidine amine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Into a solution of 1.0 g of 5-chloro-N-chlorocarbonyl-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-4-pyrimidine amine dissolved in 20 ml of toluene was added under stirring 1 ml of an aqueous 40% monomethylamine solution, and the mixture was stirred at room temperature for one hour.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-90dc54b13bfd454faef3921d52e41dfe
Source dataset
uspto-grants-1991_12
Patent number
US05073558

Reaction notes

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