Potassium Acetate → HCID 178458302, compound

HRID 1460969Notes

Reaction equation

HRID 1460969 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][CH2:18][CH3:19])[NH:5][C:6](=[O:9])[C:7]=1[NH2:8].C([O-])(=O)C.[K+].N[C:26](N)=[S:27]>>[CH2:17]([O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:4]1[N:3]=[C:2]2[C:7](=[N:8][C:26]([SH:27])=[N:1]2)[C:6](=[O:9])[N:5]=1)[CH2:18][CH3:19]

Participants

4

Reactant 3

HCID 517044Potassium AcetateHCID 2723790ThioureaHCID 1357098565,6-Diamino-2-(2-propoxyphenyl)pyrimidin-4(3H)-one

Product 1

HCID 178458302HCID 178458302, compound

Procedure

A mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one (13 g), anhydrous potassium acetate (0.34 g) and thiourea (0.96 g) was heated at 170°-180° C. for 2 hours. After digestion with water the mixture was filtered and the solid was dissolved in I Normal sodium hydroxide solution then re-precipitated by the addition of acetic acid. The dried solid was digested with chloroform and with ethanol to leave l.12 g of a crude product. Repeated recrystallisations from dimethylformamide, 2-methoxyethanol, and acetic acid yielded the title compound, 0.32 g, m.p. 305°-307° C.

Workup

  1. temperaturewas heated at 170°-180° C. for 2 hours
  2. filtrationAfter digestion with water the mixture was filtered
  3. dissolutionthe solid was dissolved in I Normal sodium hydroxide solution
  4. customthen re-precipitated by the addition of acetic acid
  5. customto leave l
  6. customrecrystallisations from dimethylformamide, 2-methoxyethanol, and acetic acid

Sources & evidence

ORD record
ord-9659b6345c99400fb0bb51d613d8c7ec
Source dataset
uspto-grants-1991_12
Patent number
US05073559

Reaction notes

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