Hydrochloric Acid → 2-(2-Propoxyphenyl)-8-methylthiopurin-6-one

HRID 1460970Notes

Reaction equation

HRID 1460970 reaction equation
[CH3:1]I.[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[N:21]=[C:20]2[C:16](=[N:17][C:18]([SH:22])=[N:19]2)[C:15](=[O:23])[N:14]=1)[CH2:4][CH3:5].[OH-].[Na+].Cl>>[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[N:21]=[C:20]2[C:16](=[N:17][C:18]([S:22][CH3:1])=[N:19]2)[C:15](=[O:23])[N:14]=1)[CH2:4][CH3:5]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178458302HCID 178458302, compound

Product 1

HCID 212507942-(2-Propoxyphenyl)-8-methylthiopurin-6-one

Procedure

Methyl iodide (0.5 g) was added to a stirred solution of 2-(2-propoxyphenyl)-8-mercaptopurin-6-one (10 g) in 1 Normal sodium hydroxide solution (8 ml). After 2.5 hours at room temperature the solution was neutralised with dilute hydrochloric acid to give the crude product which was recrystallised three times from aqueous ethanol to give the title compound, 0.32 g, m.p. 245°-247° C.

Workup

  1. customto give the crude product which
  2. customwas recrystallised three times from aqueous ethanol

Sources & evidence

ORD record
ord-51b3470680774a2c89dca6391eaf0c8e
Source dataset
uspto-grants-1991_12
Patent number
US05073559

Reaction notes

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