Diethyl [chloro(4-chlorophenyl)methyl]phosphonate → 2-[5-(4-Chlorophenylethynyl)thien-2-ylethynyl]benzothiophene
Reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]#[C:9][C:10]2[S:11][C:12]3[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)=[CH:5][CH:4]=1)=O.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26](P(=O)(OCC)OCC)Cl)=[CH:22][CH:21]=1.CC(C)([O-])C.[K+]>CN(C)C=O>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]#[C:1][C:3]2[S:7][C:6]([C:8]#[C:9][C:10]3[S:11][C:12]4[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=4[CH:14]=3)=[CH:5][CH:4]=2)=[CH:22][CH:21]=1Participants
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A stirred solution of 0.75 gram (0.0028 mole) of 2-(5-formylthien-2-ylethynyl)benzothiophene and 0.83 gram (0.0028 mole) of diethyl (4-chlorophenyl)chloromethylphosphonate in 10 ml of dimethylformamide was cooled to 0° C., and 0.94 gram (0.0084 mole) of potassium tertbutoxide was added. Upon completion of addition, the reaction mixture was stirred at 0° C. for 30 minutes and then was allowed to warm to ambient temperature where it was stirred for 18 hours. After this time the reaction mixture was subjected to column chromatography on silica gel. Elution was accomplished using hexane. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.20 gram of 2-[5-(4-chlorophenylethynyl)thien-2-ylethynyl]benzothiophene; m.p. 189°-191° C. The nmr spectrum was consistent with the proposed structure.
Workup
- additionUpon completion of addition
- temperatureto warm to ambient temperature where it
- stirringwas stirred for 18 hours
- washElution
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-e6ff885b78e642bc83fdfeade4a57314
- Source dataset
- uspto-grants-1991_12
- Patent number
- US05073564
Reaction notes
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