4-Fluoro-4'-hydroxybiphenyl → 4-[2-(4'-Fluoro-biphenyl-4-yloxy)-acetylamino]5-methyl-thiophene-3-carboxylic acid

HRID 14610Notes

Reaction equation

HRID 14610 reaction equation
C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:14])[CH2:12]Cl)=[C:8]([CH3:15])[S:7][CH:6]=1)=[O:4].[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH2:12][C:11]([NH:10][C:9]3[C:5]([C:3]([OH:2])=[O:4])=[CH:6][S:7][C:8]=3[CH3:15])=[O:14])=[CH:25][CH:24]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 3454204-Fluoro-4'-hydroxybiphenylHCID 686883434-(2-Chloro-acetylamino)-5-methyl-thiophene-3-carboxylic acid methyl ester

Product 1

HCID 160685864-[2-(4'-Fluoro-biphenyl-4-yloxy)-acetylamino]5-methyl-thiophene-3-carboxylic acid

Procedure

In analogy to Example 2, the title compound was prepared using 4-(2-chloro-acetylamino)-5-methyl-thiophene-3-carboxylic acid methyl ester [23964-99-0] and 4′-fluoro-biphenyl-4-ol. MS (m/e): 384.0 (M−H).

Sources & evidence

ORD record
ord-ed3734d12e754bea9c1f66535963ae46
Source dataset
uspto-grants-2010_06
Patent number
US07732452B2

Reaction notes

Loading…