HCID 178429711, compound → HCID 178429708, compound

HRID 1461074Notes

Reaction equation

HRID 1461074 reaction equation
[SH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10](C(O)=O)=[C:6]2[N:5]=[C:4]([CH3:14])[CH:3]=1>Cl>[CH3:14][C:4]1[CH:3]=[C:2]([SH:1])[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=1

Participants

3

Reactant 1

HCID 178429711HCID 178429711, compound

Product 1

HCID 178429708HCID 178429708, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

110 g of 7-mercapto-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid were heated to reflux temperature for 2.5 hours in 500 ml of 20 percent hydrochloric acid. The reaction mixture was cooled, the product was filtered off under suction and then recrystallized from water/ethanol at a pH of 6. There was obtained 5-methylpyrazolo [1,5-a]pyrimidine-7-thiol as yellow crystals of a melting point above 250°.

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe product was filtered off under suction
  3. customrecrystallized from water/ethanol at a pH of 6

Sources & evidence

ORD record
ord-842794255ac7449ab64a34265fbfdb8f
Source dataset
uspto-grants-1991_12
Patent number
US05073550

Reaction notes

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