Phthalic Anhydride → HCID 23373457, compound

HRID 1461099Notes

Reaction equation

HRID 1461099 reaction equation
[C:1]1(=[O:11])[O:6][C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.C([O:14][C:15](=[O:29])[CH:16]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)C.[Cl-].[Al+3].[Cl-].[Cl-]>CN(C=O)C>[CH2:23]([CH:16]([C:17]1[CH:18]=[CH:19][C:20]([C:4](=[O:5])[C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[C:1]([OH:6])=[O:11])=[CH:21][CH:22]=1)[C:15]([OH:29])=[O:14])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Participants

5

Reactant 3

HCID 6811Phthalic AnhydrideHCID 6451240Aluminum(III) ChlorideHCID 12609602HCID 12609602, compound

Product 1

HCID 23373457HCID 23373457, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The ethyl ester of the titled product was prepared in 18% yield by reacting phthalic anhydride and α-hexylbenzeneacetic acid ethyl ester in the presence of aluminum chloride in DMF according to the general procedure of Example 55. The title product was then prepared according to the procedure of Example 26 in 45% yield from the intermediate ester, m.p. 118°-121° C.

Workup

  1. customThe title product was then prepared

Sources & evidence

ORD record
ord-2807419498424c55a01bb44ee6dc4bf9
Source dataset
uspto-grants-1991_12
Patent number
US05073566

Reaction notes

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