反应详情

3.9 g (10 mmol) of 1-diphenylmethyl-3-methyl-3-[N-(ethyl)trifluoroacetylaminomethyl]azetidine in 20 ml of 5% strength sodium hydroxide and 20 ml of ethanol are stirred for one hour at 70° C. The solution is cooled, brought to pH 8 with hydrochloric acid, acidified with acetic acid and evaporated, the residue is extracted with chloroform, the organic phase is dried with anhydrous sodium sulphate, the solvent is evaporated off and 2.5 g (85%) of 1-diphenylmethyl-3-ethylaminomethyl-3-methylazetidine are obtained.

1. temperatureThe solution is cooled
2. customevaporated
3. extractionthe residue is extracted with chloroform
4. dry with materialthe organic phase is dried with anhydrous sodium sulphate
5. customthe solvent is evaporated off