Diethyl Ether → HCID 19981537, compound

HRID 1461117Notes

Reaction equation

HRID 1461117 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:8]([O:16][CH2:17][C:18]([Cl:20])=[O:19])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CCOCC>C1C=CC=CC=1>[ClH:20].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:18](=[O:19])[CH2:17][O:16][C:8](=[O:15])[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 531671-MethylpiperazineHCID 10888895Acetyl chloride, (benzoyloxy)-

Product 1

HCID 19981537HCID 19981537, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

A solution of 1-methylpiperazine (0.40 g, 4 mmole) in 5 ml benzene was added dropwise while stirring to a solution of (benzoyloxy)acetylchloride (0.80 g, 4 mmole) in 10 ml of benzene. After the addition was completed (about 10 min) the reaction mixture was stirred at room temperature for 1 h. Ether (10 ml) was added and the mixture was filtered. The white crystalline compound on the filter was washed with ether and finally recrystallized from ethanol, yielding 0.70 g (59%) of the title compound. Mp 227°-228° C.

Workup

  1. additionAfter the addition
  2. custom(about 10 min)
  3. filtrationthe mixture was filtered
  4. washThe white crystalline compound on the filter was washed with ether
  5. customfinally recrystallized from ethanol

Sources & evidence

ORD record
ord-3986dd2fd57a41cdbb635f2225bd7835
Source dataset
uspto-grants-1991_12
Patent number
US05073641

Reaction notes

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