反应详情

1.05 g of ethyl 6,6-diphenyl-8-dimethylaminonona-2,4-dienoate was dissolved in toluene (5 ml) and evaporated to dryness twice. The oil was taken up in 95% ethanol (25 ml) and placed in a Paar shaker bottle with 10% palladium on activated carbon (Pd/C, 190 mg). Paar shaker hydrogenation was conducted at room temperature and 60 psi pressure. After 1 hour, an additional 150 mg of catalyst were added and the hydrogenation reaction continued for 3 hours. TLC indicated complete reaction. The catalyst was removed by filtration, and the filtrate was concentrated to dryness to provide 863 mg of ethyl 6,6-diphenyl-8-dimethylaminononanoate, as a clear light yellow oil.

1. customevaporated to dryness twice
2. customwas conducted at room temperature
3. additionan additional 150 mg of catalyst were added
4. customthe hydrogenation reaction
5. waitcontinued for 3 hours
6. customreaction
7. customThe catalyst was removed by filtration
8. concentrationthe filtrate was concentrated to dryness