反应详情

温度

0 °C

Diphenylmethyl-7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-[(Z)-2-(1,2,3-thiadiazol-4-yl)vinyl]-3-cephem-4-carboxylate (1.6 g, 2.6 mmol) was added to a mixed solution of trifluoroacetic acid-anisole (3 ml--3 m l) cooled to 0° C. The reaction solution was stirred at 5° C. for 1.5 hours. The reaction solution was added in diisopropyl ether (100 ml) and stirred. Precipitates were collected by filtration, cleansed with diisopropyl ether and dried thereby trifluoroacetate of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-[(Z)-2-(1,2,3-thiadiazol-4-yl)vinyl]-3-cephem-4-carboxylic acid (1.13 g) was obtained.

1. stirringstirred
2. customPrecipitates
3. filtrationwere collected by filtration
4. customdried