Sodium Bicarbonate → HCID 19832782, compound

HRID 1461182Notes

Reaction equation

HRID 1461182 reaction equation
C(=O)(O)[O-].[Na+].[N:6]1[CH:11]=[CH:10][C:9]([SH:12])=[N:8][C:7]=1[SH:13].Cl.[CH2:15]([S:23]SC(=N)N)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>O.CO>[CH2:15]([S:23][S:13][C:7]1[N:8]=[C:9]([S:12][S:23][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:10]=[CH:11][N:6]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

6

Reactant 3

HCID 516892Sodium BicarbonateHCID 19979808HCID 19979808, compoundHCID 178527732HCID 178527732, compound

Product 1

HCID 19832782HCID 19832782, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of sodium bicarbonate (4.30 g; 0.05 mole) in water (60 ml) was added dropwise to a stirred suspension of pyrimidine-2,4-dithiol prepared as above (2.16 g, 0.015 mole) and S-n-octylthioisothiourea hydrochloride obtained in step (A) (7.695 g, 0.03 mole) in methanol (70 ml) at 60°-65° C. over 30 minutes. The mixture was stirred at room temperature for a further hour and then extracted into naphtha (3×50 ml). The organic extracts were washed with water, dried using anhydrous MgSO4 and evaporated yielding the product as an orange oil (5.54 g; 85%).

Workup

  1. extractionextracted into naphtha (3×50 ml)
  2. washThe organic extracts were washed with water
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-a4e5548231dc49dbb55b2d2e00fb1c8a
Source dataset
uspto-grants-1991_12
Patent number
US05075020

Reaction notes

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