Nitric Acid → HCID 19980149, compound

HRID 1461224Notes

Reaction equation

HRID 1461224 reaction equation
[N+:1]([O-:4])(O)=[O:2].S(=O)(=O)(O)O.[CH3:10][N:11]1[C:15](=[O:16])[C:14]([CH2:17][Cl:18])=[C:13]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:12]1>>[CH3:10][N:11]1[C:15](=[O:16])[C:14]([CH2:17][Cl:18])=[C:13]([C:19]2[CH:24]=[CH:23][C:22]([N+:1]([O-:4])=[O:2])=[CH:21][CH:20]=2)[O:12]1

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 19980141HCID 19980141, compound

Product 1

HCID 19980149HCID 19980149, compoundYield 87%

Procedure

After cooling 76 ml of concentrated nitric acid (specific gravity 1.42) to 0° C., 80 ml of concentrated sulfuric acid was gradually added thereto and further 9 g of 2-methyl-4 chloromethyl-5-phenyl-3-isooxazolone was added thereto as crystals thereof while keeping the temperature thereof below 5° C. The resultant mixture was stirred for 30 minutes at 5° C. and poured into 2 liters of ice water followed by stirring for one hour to deposit crystals, which were collected by filtration and dried to provide 9.4 g of the desired product. The yield was 87%.

Workup

  1. custombelow 5° C
  2. filtrationwere collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-4376206c4ca1435989cd615c67b41040
Source dataset
uspto-grants-1991_12
Patent number
US05075208

Reaction notes

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