Nitric Acid → HCID 19980149, compound

Participants

Reaction Steps

After cooling 76 ml of concentrated nitric acid (specific gravity 1.42) to 0° C., 80 ml of concentrated sulfuric acid was gradually added thereto and further 9 g of 2-methyl-4 chloromethyl-5-phenyl-3-isooxazolone was added thereto as crystals thereof while keeping the temperature thereof below 5° C. The resultant mixture was stirred for 30 minutes at 5° C. and poured into 2 liters of ice water followed by stirring for one hour to deposit crystals, which were collected by filtration and dried to provide 9.4 g of the desired product. The yield was 87%.

Provenance & Evidence